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The last mechanism is related to the pro-inflammatory effects of CRH and the potential pro-inflammatory properties of arginine vasopressin

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PGC-1 upregulates the expression of GLUT4 in skeletal muscle [103,104,105], inhibits pro-inflammatory cytokine production [106], and is a co-activator of the retinoic X receptor (RXR) [83,85,107]