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In vivo , findings demonstrate that the overexpression of indoleamine 2,3-dioxygenase (IDO) restricts ATP production in CD8+ cells, whilst in vitro studies indicate this effect is mediated by reduced activity of electron transport chain complex I, which accounts for the decreased ATP production observed in infiltrating T cells (Liu et al., 2009)
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doi: 10.1186/s12970-014-0060-9 Duan, B., Xu, J., Xing, T., Li, J., Zhang, L., & Gao, F
[DOI] [PubMed] [Google Scholar] 5.Bajramagic S., Sever M., Rasic F., Staresinic M., Skrtic A., Beketic Oreskovic L., Oreskovic I., Strbe S., Loga Zec S., Hrabar J., et al
