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However, DHODHs role appears context dependent and debated, suggesting that patient stratification (for example, mitochondrial redox burden, GPX4/FSP1 status and metabolic state) will probably determine where DHODH inhibition provides ferroptosis-relevant benefit

As a loading control, western blots were re-probed using a 1:2,500 dilution of mouse anti-GAPDH antibody (Sigma-Aldrich Chemie GmbH) followed by a 1:5,000 dilution of anti-mouse-HRP (Sigma-Aldrich Chemie GmbH)

10.1007/s00775-020-01806-y

Human Drug Compounding Safety Risks

41589_2021_915_MOESM15_ESM.mpeg Supplementary Video 13 Representative movie for 100 ns MD simulation of oxidized GPX4 U46C (C46-SOOO-) with the camera zoomed in for a close-up of the active site

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