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Nicotine can harm the adolescent brain, which continues to develop until about age 25, impacting learning, memory and attention

In addition, CS-induce pulmonary vascular endothelial cell apoptosis could promote the secretion of transforming growth factor-beta 1(TGF-1) [126, 127]

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In another study, only between 20 and 53 percent of high school students could correctly recall each of the four Surgeon General's warnings even when they were provided with the actual wording, and some incorrectly recalled having seen a warning that was not being used at the time (Ref