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The use of the glycolysis inhibitor 2-DG has been shown to alleviate the pathological condition in mice by reducing lactate accumulation, suggesting that targeting glucose metabolism may be a potential strategy for treating PD [88]

There is insufficient evidence for the use of B12, beyond correction of deficiency, in cognitive impairment, depression and fatigue

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M., Wilson S

Notably, encompassed RCTs were those that assessed the use of vitamin C as an intervention, comprising the comparison group on placebo, reporting on any quantifiable outcome of CVD in patients with diabetes or metabolic syndrome