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Patients with early hereditary optic nerve atrophy, cyanocobalmin hypersensitivity, and those who are pregnant

Treatment involves addressing the cause and sometimes vitamin B12 supplements or injections

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In addition to the reported GI blood loss that can play a role in iron deficiency seen in endurance athletes, such as marathon and distance runners, I think that excess sweating may also play a role in why iron deficiency is so common in these types of athletes