As B12 helps make red blood cells, a lack of vitamin B12 can cause anemia
Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)
Vitamin B12 deficiency can cause fatigue, memory and cognitive loss, myalgias(leg and back pain), poor digestion, mood changes, hair loss, weight gain due to poor metabolism
Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis
NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% in diet-induced obese mouse models without suppressing food intake, suggesting energy expenditure modulation
It is naturally found in animal-based foods such as meat, fish, eggs, and dairy