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2020;15:e0229002

The first reaction is rate limiting and is catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2

Research-grade material is not guaranteed for sterility, endotoxin, or purity the way an approved parenteral drug is

Synthetic insulin, for example, has been used for decades to manage diabetes, dramatically improving many lives

Additional steps may be taken (e.g., deproteinization and/or storage at 80 o C) to prevent a variety of processes from altering GSH levels (e.g., enzymatic degradation of GSH

Engle MJ, Volpe JJ (1990) Glutamine synthetase activity of developing astrocytes is inhibited in vitro by very low concentrations of lead