50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering
Downstream TERT activation elongates critically short telomeres (measured by Southern blot TRF analysis, or by qPCR telomere length ratio T/S), delays the p16-p21-Rb senescence programme (SA--gal pH 6.0 reduction, p16 Ink4a western blot decrease), and reduces the senescence-associated secretory phenotype (SASP: IL-6, IL-8, MMP-1, MMP-3, GDF15 multiplex Luminex panel in conditioned media from late-passage HDFs)
The BPC-157 ARG + KPV blend combines three peptide-based compounds that are commonly studied for tissue repair, inflammation regulation, gut health support, and recovery enhancement
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PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis
Reduces neuroinflammation, promotes neuroplasticity, and protects neurons from stress damage