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Polymorphisms in the SOD3 gene have been linked to type 2 diabetes, ischemic heart disease, acute lung injury and COPD

In the body, O 2 - anions are intended products of redox signaling enzyme cascade and byproducts of several metabolic processes including mitochondrial respiration 555

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Glutathione is decisive in either limitingor preventing the harmful effects induced by free radicals,and canprotect the body from oxidising agents, such as pesticides, hydrogen sulphide, carbon monoxide, heavy metals (mercury, cadmium and chromium), cigarette smokeand many other substances we come in contact withdue to pollution of the atmosphere and of foodstuffs

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They also generate reactive oxygen species during normal metabolism