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The authors proposed that MOTS-c levels could serve as a predictive indicator for aerobic capacity, body-fat status, and endurance training load.14 This raises an intriguing possibility for endurance practitioners: MOTS-c as a blood-based biomarker for mitochondrial fitness, complementing VOmax and lactate threshold in a multi-modal assessment framework

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This conformational restriction prevents the peptide from adopting flexible substrate orientations that proteases require for efficient cleavage