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While Johnsons approach may be extreme, there are practical, evidence-based strategies that can support longevity without an exhaustive blueprint: Metformin Traditionally used for type 2 diabetes, Metformin has shown promise in extending lifespan by improving metabolic health and reducing age-related inflammation

PMID: 41139215 Nat Commun A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses

Pharmacogenomics J 2:297308 Raftogianis RB, Wood TC, Otterness DM, Van Loon JA, Weinshilboum RM (1997) Phenol sulfotransferase pharmacogenetics in humans: association of commonSULT1A1alleles with TS PST phenotype

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