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Other proposed mechanisms include direct interaction with cell surface integrins (particularly alpha-2-beta-1), effects on iron metabolism through copper-iron regulatory interactions, and epigenetic modifications

Research models focus on pathway convergence signalling sequencing and molecular cooperation between cytoprotective and structural regulatory systems

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Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer