Yeah, immediately yelling for help is crazy
25-OHC treatment significantly inhibited sterol regulatory element-binding protein (SREBP) expression in IMS32 Xuewang cells, downregulated GXP4 and stearoyl-CoA desaturase 1 (SCD1), and upregulated PTGS2, thereby increasing intracellular ROS levels and promoting ferroptosis
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In addition to regulating ferroptosis pathways, flavonoids also target multiple genes and signaling pathways, including nuclear receptors, aryl hydrocarbon receptor (AhR), kinases, receptor tyrosine kinases (RTKs), and G protein-coupled receptors (GPCRs) (Safe et al., 2021)
The effect of HMG-CoA reductase inhibitors on coenzyme Q10: possible biochemical/clinical implications