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5 Polycystic ovary syndrome is the most common hormonal disorder in women of reproductive age and usually develops during the early stages of puberty

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The over-expression of COX-1 was found to occur in normal gastric mucosa, whereas COX-2 mRNA and protein are undetectable in normal tissues, but become abundant in activated macrophages and other cells at the site of inflammation as well as in human malignancies and animal models of carcinogenesis (23, 81-85)