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The evidence shows no meaningful benefit for healthy people with normal B12

Setting realistic expectations prevents discouragement during the initial phase when progress may not yet be visible

However, if you are prone to allergic reactions, pregnant, or breastfeeding, it is advisable to avoid this treatment

In January 2025 , a narrative review in Cureus evaluated the efficacy and safety of oral, topical, and intravenous glutathione for skin lightening

BMC Complement Med Therap

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