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(194) involving 308 patients revealed that combining surgery with medical therapy lowered mortality from 32.7% to 6.7%

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Indeed, there are case reports of monozygotic twins harboring the exact same mutation, both with elevated serum very long chain fatty acids (indicating a similar metabolic defect of peroxisomal lipid processing), where one boy is affected clinically and radiologically, while his twin brother is completely normal (Korenke et al., 1996)

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