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CPT: Pharmacometrics & Systems Pharmacology

Many chemicals have been reported to induce ER stress and subsequently cause toxicity in hepatic and extra-hepatic cells (Ren et al., 2016

reduced glutathione detoxifies reactive oxygen species such as hydrogen peroxide, preventing them from causing oxidative stress ( Figure 1 )

Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain

It has been confirmed as a novel metabolite of Hcy, which is generated by the conversion of Hcy to Hcy-thiolactone catalyzed by methionyl-tRNA synthetase 15

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