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Considerations for the sensible use of rodent models of inflammatory disease in predicting efficacy of new biological therapeutics in the clinic

Additionally, following the injection, it is recommended to rest the hand and avoid activities that may exacerbate symptoms

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Evidence at a Glance Key Takehome No peptide has demonstrated efficacy for dementia prevention in humans

Neurogenic inflammation Neurogenic inflammation involves the enhanced release of proinflammatory neuropeptides (such as substance P) from sensory and/or sympathetic nerves, which can lead to persistent afferent nerve sensitization and local inflammatory changes

For the spray, one dose twice daily with 30-60 seconds of sublingual holding is recommended