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P., Kokare, D

Given that PKC signaling pathway is also significantly downregulated in GPR146 knockdown cells from our phosphoproteomics study, we next tested whether GPR146 regulates adipogenesis by coupling to Gq

Investigators have described this pattern as a "broad reset" of pathways associated with cellular aging language that, while evocative, remains pre-clinical and has not been translated into validated human therapeutic claims

In addition, lactate-mediated histone lactylation has been implicated in stabilizing Treg lineage commitment and functional persistence, further contributing to immune tolerance within TME [118]

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The pathological state of both elevated B12 and MMA is predominantly described in diabetes and geriatric patients, termed functional B12 deficiency