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Factors like disrupted gut microbiota, chronic anemia, and excess ROS increase the risk of drug interactions leading to systemic allergic reactions

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Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al (2012) Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association