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Arthritis Res Ther 17:364 Srinivasan V et al (2012) Melatonin and its agonists in pain modulation and its clinical application

That editorial included a caveat that vitamin D supplementation remained an open area of investigation, particularly in deficient persons but nevertheless concluded that current widespread use [of vitamin D supplements] is not based on solid evidence that benefits outweigh harms. Also last year, a study from Massachusetts General Hospital found that many of the 70 percent to 90 percent of African-Americans diagnosed as vitamin D deficient may actually have healthy levels of the vitamin and are not deficient because they are genetically disposed to carry more of the free form of the nutrient

For elderly individuals, especially those with absorption issues, higher doses might be necessary to meet their nutritional needs

animal-only, not clinically validated