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Beni-Suef Univ J Basic Appl Sci 10 , 85 (2021)

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Another mechanism by which the endo/lysosomal compartment can influence APAP-induced hepatotoxicity is through the clearance of damaged mitochondria in a process also called mitophagy, consisting in the degradation of dysfunctional mitochondria by lysosomal proteases upon fusion of the autophagosomes-containing mitochondria with lysosomes, which is discussed in the next section

Although some patients report significant relief from symptoms like inflammation and fatigue, others experience only a placebo effect