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In TGR, and more generally in TrxRs, electron transfer from NADPH to the enzyme is fast and practically irreversible and so an actual ES complex (NADPH-TGR) is not significantly populated during the catalytic cycle 17

Acknowledgments We thank our study volunteers for providing samples and supporting this work and the clinical staff for their dedication to this research

Higher doses up to 600 mg are sometimes used in clinical fertility settings but should be discussed with a clinician

The statistical analysis was performed using XLStats 2017 software (Addinsoft, New York, NY)

No alternatives to PZQ are currently available and few drugs or vaccines are in the clinical pipeline for schistosomiasis treatment 6,7,8

The wild type flies, irrespective of their treated conditions showed strong negative geotaxis through a vertical column