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NAM treatment increased mitochondrial NAD + /NADH ratios and improved mitochondrial membrane potential in human primary cells 115

Collectively, these data demonstrate that NSW disrupts both the expression and methylation status of core circadian clock genes involved in BC etiology, such as PER1, PER2, BMAL1, and CLOCK (Fig

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however, this has been done in other stem cells contexts, which could presumably overlap with critical NSC pathways

Keap1 is an adaptor component of Cullin 3 (Cul3)-based ubiquitin E3 ligase that enhances the ubiquitylation of Nrf2, which promotes the degradation of Nrf2 in proteinsome (Uruno and Yamamoto, 2023