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Simultaneously, ROS activates MAPKs such as p38 and JNK, increasing the expression of inflammatory mediators and MMPs, which accelerate BBB breakdown (Figure 3) [191,192]

Supplementary Figure 10 Metabolic pathway enrichment analysis plot shows significantly altered pathways in A vs LC

And the everyday culprits that disrupt digestion, such as stress, caffeine, alcohol, inflammation, age, medications, gut irritation, rushing meals, even tiredness, disrupt absorption too

The recommended dosage and frequency will be determined by your doctor and your bodys ability to store vitamin B12