Several biological DMARDs have recently emerged including TNF-inhibitor (Amjevita, Renflexis, Erelzi, Cyltezo, Imradl), anti-CD20 antibody (Truxima, Rixathon), IL-6 receptor antibody (Kevzara), RANKL antibody (Pralia), and JAK inhibitor (Olumiant)
The mechanism proves highly effective for expression wrinkles driven by repetitive muscle contractions - forehead lines from frontalis muscle activity, crow's feet from orbicularis oculi contractions, and frown lines from corrugator and procerus muscles creating habitual scowling patterns diminish dramatically when underlying muscle activity ceases through neurotoxin intervention as established through decades of clinical use
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