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As cited in the 3 case reports, caffeine was shown to induce inflammation in animal experimentsit induced smooth muscle relaxation through the adenosine A 2b receptor, suppressed the functions of mononuclear cells and macrophagocytes, and increased the emission of mast cell mediators

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Centers for Disease Control and Prevention (2007) Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network, 13 sites, United States, 2002