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Validation strategies, split-sample testing, permutation analyses, and receiver operating characteristic (ROC) curves, have confirmed the discriminatory capacity of small metabolite panels (46 compounds), with many models reaching area under the curve (AUC) values greater than 0.85

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Nutrients (2020) 12(1):222

I noticed a small decrease in systolic BP

However, studies have shown that Tregs in HFD mice VAT decrease with age, and Treg cells are also significantly reduced in obese patients (153, 154)

If you experience unexplained weight changes while taking any supplement, consult your doctor to rule out other causes