Controlled trials in age-related diseases: e.g., osteoarthritis, chronic kidney disease, endocrine decline, frailty syndrome, possibly cardiovascular ageing
Chronic inflammation is probably the biggest driver, whether from gut infections like SIBO or candida, autoimmune conditions, or persistent immune activation
However, it is unclear whether NCOA4 can bind to the cell membrane before translocating to the cytoplasm, apart from the evidence demonstrating its truncated isoform SRC3s ability to bind to the cell membrane [44]
By supporting natural detox pathways, this therapy can help reduce the burden of environmental pollutants, alcohol, medications, and processed foods
Thank you to our sponsors AGZ by AG1: LMNT: David: Timestamps 0:00 Social Connection 1:10 Social Bonds, Social Isolation & Stress Hormones 3:09 Sponsor: LMNT 4:42 Brain & Social Homeostasis
The Phase 2 SHAPE trial (NCT04831281) in Parkinsons disease dementia and dementia with Lewy bodies failed its primary endpoint in December 2023