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This specific impairment of mitochondrial energy metabolism, combined with the downregulation of key cell cycle regulators such as c-Myc and Cyclin D1, provides a direct mechanistic explanation for the observed S-phase arrest and growth inhibition

Allewaert CC, Hiegle N, Strittmatter M, de Blok R, Guerra T, Gachon CMM, Vyverman W

& Loutzenhiser, R

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Importantly, evidence from tissue-specific transgenic or knockout animal models of PGC-1s have supported this notion