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B12 injections can also rapidly replenish B12 levels in cases of deficiency, providing relief from symptoms such as fatigue, weakness, and neurological problems

MOTS-c has no relationship to this axis at all

Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency

The structural formula is represented below

As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate

When uncertain, administer separately