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Biomarker assessment reveals actual depletion rather than assuming deficiency based on symptoms alone

Mitochondrial dysfunction in bipolar depression There has been a recent conceptualization of BD as a mitochondrial disorder, with the suggestion that energy production is increased in mania and decreased in the depressive phase [30, 31]

(2021) 13:eabb0319

In the enteric system, 90% of total tryptophan is produced via the kynurenine pathway, which also generates kynurenic and quinolinic acids that are essential for the operation of the enteric and central nervous systems, respectively (Gheorghe et al., 2019)