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Thorax 67 , 689693 (2012)

doi: 10.1111/jpi.12992 56 WangG.QinS.ChenL.GengH.ZhengY.XiaC.et al

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and consulting fees from Faeth Therapeutics, Vividion Therapeutics Calithera, ONCO0 Inc and Tohoku University outside the submitted work

Upon activation, Nrf2 translocates to the nucleus, where it binds to antioxidant response elements (AREs) in the DNA, upregulating the production of cellular antioxidant enzymes and other cytoprotective proteins [33]