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Increased FAO may be an adaptive response in patients with NAFLD attempting to reduce the lipid overload and lipotoxicity, but also produces ROS and excessive FAO may overwhelm the capacity of the anti-oxidant defense system and induce oxidative stress

ASCA is a useful tool for large longitudinal cohorts, as many factors (e.g., season of measurement) can indirectly influence the results 43

Communication between the nervous system and endocrine system depends upon precisely coordinated signalling networks that regulate hormone release and physiological balance