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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

For those who prefer a more natural approach, remedies like turmeric, lemon juice, aloe vera, and sandalwood can help lighten skin gradually

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261266, pubmed.ncbi.nlm.nih.gov/24149870/