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The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

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(2009) demonstrated that glutathione plays a crucial role in cellular detoxification and oxidative stress reduction, protecting healthy cells from damage

This reduces the amount of active ingredient that reaches the cells, a particularly evident limitation for glutathione, whose oral bioavailability is rather low

In this way, glutathione acts as a protective shield, ensuring that harmful substances do not accumulate and cause further damage to cellular structures