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Furthermore, BAs contribute to the regulation of glucose and lipid metabolism through FXR and TGR5 activation (66)

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600 In a multicenter, randomized, double-blind, placebo-controlled trial, canagliflozin did not affect the risk of neuropathy events

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[1] [2] It functions primarily within the mitochondriathe cellular powerhouseswhere it participates in the electron transport chain to generate adenosine triphosphate (ATP), the body's primary energy currency

We also asked if genetically increasing the glutaryl-CoA pool (the donor for glutarylation) altered glutaryl modifications and generated GCDH-deficient HeLa cells (Supplementary Fig