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For individuals with a B12 deficiency, injections may help restore energy levels and improve overall well-being, which could indirectly support more active behavior and possibly weight management

Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J Med Chem , 2017;60(12):5015-5028

And you have a bad fight

Even if you have enough vitamin B12 in your system, inhaling nitrous oxide can prevent your body from accessing and using the vitamin

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement