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From a molecular viewpoint, key mechanistic themes have emerged: microbial metabolites such as SCFAs, tryptophan metabolites, and bile acids can penetrate into the CNS or signal via the vagus, modulating microglial activation, astrocytic support, and even neuronal gene expression

Among these pathways, Alzheimer disease, Serotonergic synapse, Calcium signaling pathway, Amyotrophic lateral sclerosis (ALS), Glutamatergic synapse, Cholesterol metabolism, Long-term potentiation, Phagosome, Immune system, and TNF signaling pathway belong to at least two perspectives (Fig

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A 2023 randomized, phase 2 crossover trial by Hansen et al

Link Maczurek, A., Hager, K., Kenklies, M., et al

HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis