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Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimers disease

The export of cholesterol from the lysosomal lumen by NPC1 is essential for the regulation of mTORC1 signalling, thus mutations resulting in the inactivation of NPC1 will not only result in the accumulation of cholesterol but also as the hyperactivation of mTORC1, whose activation is often associated with cancer [39]

Research is also clear of the impact that vitamin D deficiency has on thyroid health and it isnt pretty

This actions gives it a high detoxifying power of harmful endogenous substances

Nillert N, Pannangrong W, Welbat JU, Chaijaroonkhanarak W, Sripanidkulchai K, et al

10.1016/j.mcna.2021.06.008 185